Document 0087
 DOCN  M9480087
 TI    Anti-HIV michellamines from Ancistrocladus korupensis.
 DT    9410
 AU    Boyd MR; Hallock YF; Cardellina JH 2nd; Manfredi KP; Blunt JW; McMahon
       JB; Buckheit RW Jr; Bringmann G; Schaffer M; Cragg GM; et al; Laboratory
       of Drug Discovery Research & Development, National; Cancer
       Institute-Frederick Cancer Research & Development Center,; Maryland
       21702-1201.
 SO    J Med Chem. 1994 Jun 10;37(12):1740-5. Unique Identifier : AIDSLINE
       MED/94293292
 AB    Here we report details of the isolation and determination of the
       absolute configurations and comparative anti-HIV activities of novel,
       atropisomeric naphthylisoquinoline alkaloid dimers, michellamines A, B,
       and C, from a newly described species of Ancistrocladus from the Korup
       rainforest of Cameroon. We further provide a more extensive analysis of
       the range of anti-HIV activity of michellamine B, the most potent and
       abundant member of the series. Michellamine B inhibited HIV-induced cell
       killing and viral replication in a variety of human cell lines, as well
       as in cultures of human peripheral blood leukocytes and monocytes.
       Michellamine B was active against a panel of biologically diverse
       laboratory and clinical strains of HIV-1, including the AZT-resistant
       strain G910-6 and the pyridinone-resistant strain A17; the compound also
       inhibited several strains of HIV-2.
 DE    Africa  Antiviral Agents/CHEMISTRY/ISOLATION & PURIF/*PHARMACOLOGY
       Cells, Cultured  Drug Interactions  Human  HIV/*DRUG EFFECTS/PHYSIOLOGY
       HIV-1/DRUG EFFECTS  HIV-2/DRUG EFFECTS
       Isoquinolines/CHEMISTRY/ISOLATION & PURIF/*PHARMACOLOGY  Microbial
       Sensitivity Tests  Molecular Structure  Naphthalenes/CHEMISTRY/ISOLATION
       & PURIF/*PHARMACOLOGY  Plants/*CHEMISTRY  Support, Non-U.S. Gov't  Virus
       Replication/DRUG EFFECTS  Zidovudine/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).