Document 0089
 DOCN  M9480089
 TI    Oral candidiasis and immune status of HIV-infected patients.
 DT    9410
 AU    Nielsen H; Bentsen KD; Hojtved L; Willemoes EH; Scheutz F; Schiodt M;
       Stoltze K; Pindborg JJ; Department of Oral Pathology, School of
       Dentistry, University of; Copenhagen, Denmark.
 SO    J Oral Pathol Med. 1994 Mar;23(3):140-3. Unique Identifier : AIDSLINE
       MED/94293201
 AB    A total of 84 HIV-infected homosexual men having either normal oral
       mucosa (NOM), erythematous candidiasis (EC) or pseudomembranous
       candidiasis (PsC) were included in the study. The patients were
       evaluated by median number of peripheral CD4+ cells, CD8+ cells and by
       lymphocyte function assessed by poke-weed mitogen test. There was a
       significant difference between CD4+ counts among patients with the two
       subtypes of candidiasis (95% CI of median difference: 10-240/mm3; P =
       0.03), but not for pokeweed mitogen response. Survival analysis showed
       that after 2 y there was no significant difference in development of
       AIDS between patients with EC and PsC (P = 0.29). If patients with both
       types of oral candidiasis were pooled and compared with patients with
       NOM, a significant difference in development of AIDS was found (P =
       0.04). It is concluded that HIV-infected patients with oral candidiasis
       of any subtype (EC or PsC) are significantly more immune suppressed and
       show a faster development of AIDS than HIV-infected patients with NOM.
       However, in this cohort, EC and PsC are of equal importance as
       predictors for immune suppression and AIDS development.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Adult  Candidiasis,
       Oral/*IMMUNOLOGY/PATHOLOGY  Cohort Studies  Follow-Up Studies  Human
       HIV Infections/*IMMUNOLOGY  HIV Seropositivity/*IMMUNOLOGY  Leukocyte
       Count  Longitudinal Studies  Lymphocyte Transformation  Male  Middle Age
       Mouth Mucosa/*IMMUNOLOGY  T-Lymphocytes, Cytotoxic/IMMUNOLOGY/PATHOLOGY
       T4 Lymphocytes/IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

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