Document 0090
 DOCN  M9480090
 TI    Comparison of a lesion-inducing isolate and a non-lesional isolate of
       Candida albicans in an immunosuppressed rat model of oral candidiasis.
 DT    9410
 AU    Allen CM; Saffer A; Meister RK; Beck FM; Bradway S; Section of Oral and
       Maxillofacial Surgery and Pathology, Ohio; State University, Columbus
       43210.
 SO    J Oral Pathol Med. 1994 Mar;23(3):133-9. Unique Identifier : AIDSLINE
       MED/94293200
 AB    Two distinct strain-related patterns of organism-host interaction on
       dorsal tongue of immunocompetent rats have been identified for Candida
       albicans: some isolates induce mucosal lesions, while other isolates
       penetrate the keratin layer but do not produce a lesion. This study
       examined the behavior of each of the two types of isolates in a
       cyclosporin-immunosuppressed rat model. Groups B (normal) and D
       (cyclosporin) were orally inoculated with a lesion-inducing isolate of
       C. albicans, while a non-lesional isolate was given to Groups A (normal)
       and C (cyclosporin). A typical dorsal tongue lesion developed in 4/18
       rats in Group B and in 13/16 in Group D (P = 0.00267). No significant
       difference in infection rate between the normal and cyclosporin-treated
       animals was seen for the non-lesional isolate. The lack of a host
       inflammatory response associated with the non-lesional isolate may
       represent an ecologic advantage for the organism.
 DE    Animal  Candida albicans/*CLASSIFICATION/ISOLATION & PURIF/*PHYSIOLOGY
       Candidiasis, Oral/*MICROBIOLOGY/PATHOLOGY  Comparative Study
       Cyclosporine  CD4-CD8 Ratio  Ecology  Female  Graft Rejection/PATHOLOGY
       *Immunocompromised Host  Keratin  Mouth Mucosa/MICROBIOLOGY/PATHOLOGY
       Rats  Rats, Inbred ACI  Rats, Sprague-Dawley  Skin
       Transplantation/IMMUNOLOGY/PATHOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes, Helper-Inducer/PATHOLOGY  T-Lymphocytes,
       Suppressor-Effector/PATHOLOGY  Tongue/*MICROBIOLOGY/PATHOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).