Document 0123
 DOCN  M9480123
 TI    Circulating cytotoxic T lymphocyte precursors in maedi-visna
       virus-infected sheep.
 DT    9410
 AU    Blacklaws BA; Bird P; Allen D; McConnell I; Department of Veterinary
       Pathology, University of Edinburgh,; Summerhall, U.K.
 SO    J Gen Virol. 1994 Jul;75 ( Pt 7):1589-96. Unique Identifier : AIDSLINE
       MED/94292909
 AB    Maedi-visna virus (MVV)-specific cytotoxic T lymphocytes (CTL) were
       detected, after in vitro culture with MVV antigen and recombinant human
       interleukin-2, in the efferent lymph and peripheral blood of sheep
       chronically infected with MVV. Cytotoxicity was mediated by CD8+
       lymphocytes and was specific for particular strains of MVV. These
       precursor CTL were detected in the blood between day 23 and day 100
       after infection via the skin. In one out of seven persistently infected
       sheep MVV-specific cytotoxicity was seen in uncultured peripheral blood
       cells. Again the effector population consisted of CD8+ lymphocytes. The
       only other viral infections in which CTL have been detected in
       peripheral blood mononuclear cells prior to secondary stimulation are
       those caused by the simian and human immunodeficiency viruses.
 DE    Animal  Antigens, CD8/ANALYSIS  Cells, Cultured  Cytotoxicity,
       Immunologic/DRUG EFFECTS/*IMMUNOLOGY  Disease Models, Animal  Human  HIV
       Infections/IMMUNOLOGY  Interleukin-2/PHARMACOLOGY  Leukocytes,
       Mononuclear  Lymph/CYTOLOGY  Pneumonia, Progressive Interstitial, of
       Sheep/*IMMUNOLOGY/  MICROBIOLOGY  Sheep  Simian Acquired
       Immunodeficiency Syndrome/IMMUNOLOGY  Skin  Support, Non-U.S. Gov't
       T-Lymphocyte Subsets/IMMUNOLOGY  T-Lymphocytes, Cytotoxic/*IMMUNOLOGY
       Visna-Maedi Virus/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).