Document 0142
 DOCN  M9480142
 TI    Is there IgA of gut mucosal origin in the serum of HIV1 infected
       patients?
 DT    9410
 AU    Quesnel A; Moja P; Lucht F; Touraine JL; Pozzetto B; Genin C; Laboratory
       of Research in Immunology, University of; Saint-Etienne, INSERM, Lyon,
       France.
 SO    Gut. 1994 Jun;35(6):803-8. Unique Identifier : AIDSLINE MED/94292010
 AB    This study was performed in 77 HIV1 seropositive adult patients to
       characterise the IgA hyperglobulinaemia seen in the serum during the
       course of HIV infection. It was shown that both IgA1 and IgA2 subclass
       concentrations were simultaneously increased but the IgA1 increase was
       predominant. Secretory IgA (SIgA) concentration was significantly
       increased and IgA activity to gliadin, bovine serum albumin, and casein
       could be detected and was correlated with SIgA concentration. In
       contrast, IgA activity to cytomegalovirus and to tetanus toxoid did not
       correlate with total IgA concentration. These data suggest the presence
       of IgA from gut mucosal origin in the serum of these patients. Hyper IgA
       was inversely correlated with the CD4+ cell number. The increase of all
       parameters studied varied according to the total IgA concentration in
       the serum but was also directly related to the stage of immune
       deficiency in patients with hyper IgA.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Adult  Aged  Antibodies,
       Viral/BLOOD  Antigenic Determinants/ANALYSIS  Caseins/IMMUNOLOGY
       Cytomegalovirus/IMMUNOLOGY  Female  Gliadin/IMMUNOLOGY  Human
       HIV-1/*IMMUNOLOGY  IgA/*BLOOD  IgA, Secretory/BLOOD  IgG/BLOOD
       Intestinal Mucosa/*IMMUNOLOGY  Leukocyte Count  Male  Middle Age  Serum
       Albumin, Bovine/IMMUNOLOGY  Support, Non-U.S. Gov't  T4 Lymphocytes
       JOURNAL ARTICLE

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