Document 0144
 DOCN  M9480144
 TI    Haemochromatosis as a window into the study of the immunological system:
       a novel correlation between CD8+ lymphocytes and iron overload.
 DT    9410
 AU    Porto G; Reimao R; Goncalves C; Vicente C; Justica B; de Sousa M; Abel
       Salazar Institute for the Biomedical Sciences, Santo Antonio; General
       Hospital, Porto, Portugal.
 SO    Eur J Haematol. 1994 May;52(5):283-90. Unique Identifier : AIDSLINE
       MED/94291806
 AB    In the present study we report a serial investigation of the numbers of
       the peripheral blood cells--erythrocytes, polymorphonuclear neutrophils,
       total lymphocytes, T-lymphocyte subpopulations (CD2, CD4, CD8), B
       lymphocytes and monocytes--in a group of 21 patients with
       haemochromatosis during the time of intensive phlebotomy treatment,
       i.e., from iron overload until the onset of iron deficiency. A
       remarkable individual stability of all blood cell populations studied
       was found in all patients. Patients differed in their relative
       proportions of CD4+ and CD8+. Each individual's CD4/CD8 ratio, as well
       as the absolute numbers, remained unaffected with time, confirming the
       existence of a strict homeostatic regulation of the relative numbers of
       the two major peripheral T lymphocytes. A significant positive
       correlation between CD4/CD8 ratios and the amount of iron mobilised by
       phlebotomy was found during this study. A novel correlation between the
       relative proportions of CD4+ and CD8+ cells and iron overload is
       confirmed by the follow-up of iron re-entry in the serum transferrin
       pool in the treated patients.
 DE    Adult  Aged  Bloodletting  CD4-CD8 Ratio  Female
       Hemochromatosis/*IMMUNOLOGY/METABOLISM  Human  Leukocyte Count  Male
       Middle Age  Support, Non-U.S. Gov't  T-Lymphocytes/*IMMUNOLOGY  Time
       Factors  Transferrin/METABOLISM  JOURNAL ARTICLE

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