Document 0145
 DOCN  M9480145
 TI    Different proliferative response of human and chimpanzee lymphocytes
       after contact with human immunodeficiency virus type 1 gp120.
 DT    9410
 AU    Di Rienzo AM; Furlini G; Olivier R; Ferris S; Heeney J; Montagnier L;
       Department of Retroviruses, Institut Pasteur, Paris.
 SO    Eur J Immunol. 1994 Jan;24(1):34-40. Unique Identifier : AIDSLINE
       MED/94291738
 AB    T cell functional defects are a common aspect of human immunodeficiency
       virus (HIV) infection. Moreover, it has been suggested that indirect
       mechanisms are involved in CD4+ cell depletion. Unresponsiveness to
       proliferative stimuli of lymphocytes incubated with HIV particles or
       with viral proteins is well documented. Nevertheless, drawing a clear
       picture of the anergy phenomenon is difficult because of several
       unresolved and controversial questions. Here we report that recombinant
       gp120 induces anergy in T helper lymphocytes cultured with different
       stimuli. The proliferative responses to interleukin (IL)-2, IL-4, IL-6,
       anti-CD2, anti-CD3 and phorbol 12-myristate 13-acetate are inhibited.
       Moreover, anergic cells show a different distribution in cell cycle
       phases as compared to control cells, leading us to suggest that the
       progression in the cell cycle is hampered and that a pre-mitotic block
       takes place. Furthermore, since chimpanzees are susceptible to HIV-1
       infection without showing immunodeficiency signs, we analyzed the
       proliferation of chimpanzee lymphocytes without observing anergy in
       cells preincubated with gp120. Taken together, these results support the
       hypothesis that anergy plays an important role in HIV infection in vivo.
 DE    Animal  Cell Cycle/IMMUNOLOGY  Chimpansee troglodytes  Comparative Study
       Gene Products, env/IMMUNOLOGY  Human  HIV Envelope Protein
       gp120/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Immune Tolerance  Lymphocyte
       Transformation/*IMMUNOLOGY  Protein Precursors/IMMUNOLOGY  Recombinant
       Proteins/IMMUNOLOGY  Species Specificity
       T-Lymphocytes/IMMUNOLOGY/PHYSIOLOGY  JOURNAL ARTICLE

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