Document 0152
 DOCN  M9480152
 TI    Significance of interleukin 6 in patients with sarcoidosis.
 DT    9410
 AU    Sahashi K; Ina Y; Takada K; Sato T; Yamamoto M; Morishita M; Second
       Department of Internal Medicine, Nagoya City, University; Medical
       School, Japan.
 SO    Chest. 1994 Jul;106(1):156-60. Unique Identifier : AIDSLINE MED/94291373
 AB    Interleukin 6 (IL-6) levels in various materials from patients with
       sarcoidosis were determined. The subjects of the study were 38 patients
       with sarcoidosis and 28 healthy controls. For detection of IL-6, an
       enzyme-linked immunosorbent assay method was used. Interleukin 6
       activity in serum was detected in 4 of 30 patients, but not in 19
       controls. In bronchoalveolar lavage (BAL) fluid, following 20-fold
       concentration, IL-6 activity was detected in four of ten patients
       (nonsmokers) and three of seven controls (two of two smokers and one of
       five nonsmokers). Interleukin 6 levels in the supernatants of cultured
       monocytes and alveolar macrophages (AMs) were significantly higher (p <
       0.01 and p < 0.01, respectively) in patients with sarcoidosis than in
       controls. Interleukin 6 production from monocytes tended to correlate
       with that from AMs. A significant correlation (r = 0.70, p < 0.05) was
       found between IL-6 production from AMs and the ratio of CD4+/CD8+ in BAL
       fluid, although no correlation was observed between that from monocytes
       and CD4+/CD8+ ratio in BAL fluid. Taken together, IL-6 may be involved
       in the initiation and maintenance of alveolitis by activating and
       causing the proliferation of T cells.
 DE    Adult  Bronchoalveolar Lavage Fluid/CHEMISTRY  Cells, Cultured  CD4-CD8
       Ratio  Female  Human  Interleukin-6/*ANALYSIS  Macrophages,
       Alveolar/METABOLISM  Male  Middle Age  Monocytes/METABOLISM
       Sarcoidosis/IMMUNOLOGY/*METABOLISM  Support, Non-U.S. Gov't  Tumor
       Necrosis Factor/ANALYSIS  JOURNAL ARTICLE

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