Document 0154
 DOCN  M9480154
 TI    Long-term dietary vitamin E retards development of retrovirus-induced
       disregulation in cytokine production.
 DT    9410
 AU    Wang Y; Huang DS; Eskelson CD; Watson RR; Department of Family and
       Community Medicine, University of; Arizona, Tucson 85724.
 SO    Clin Immunol Immunopathol. 1994 Jul;72(1):70-5. Unique Identifier :
       AIDSLINE MED/94291303
 AB    A 15-fold increase in dietary vitamin E (160 IU/liter) normalized
       hepatic and serum levels of vitamin E normally reduced by retrovirus
       infection. It also significantly retarded development of splenomegaly
       and hypergammaglobulinemia induced by retrovirus infection, while
       significantly restoring release of interleukin-2 (IL) and
       interferon-gamma by splenocytes which are suppressed by retrovirus
       infection. Retrovirus infection elevated production of IL-4 and IL-6 by
       splenocytes, but this elevation was inhibited by vitamin E. Increased
       levels of IL-6 and tumor necrosis factor-alpha produced by splenocytes
       during progression to murine AIDS were also inhibited by vitamin E.
       Vitamin E supplementation also helped restore retrovirus-suppressed
       splenocyte proliferation. These data indicate that vitamin E
       supplementation can help overcome retrovirus-induced reduction in tissue
       vitamin E, modulate cytokine release, and normalize immune dysfunctions
       during progression to murine AIDS.
 DE    Animal  Antibodies, Monoclonal  Cell Division/DRUG EFFECTS
       Cytokines/*BIOSYNTHESIS/*IMMUNOLOGY  Diet  Enzyme-Linked Immunosorbent
       Assay  Female  Hypergammaglobulinemia/MICROBIOLOGY/THERAPY  Mice  Mice,
       Inbred C57BL  Murine Acquired Immunodeficiency
       Syndrome/*IMMUNOLOGY/*THERAPY  Spleen/CYTOLOGY
       Splenomegaly/MICROBIOLOGY/THERAPY  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes, Helper-Inducer/IMMUNOLOGY  Vitamin E/*PHARMACOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).