Document 0162
 DOCN  M9480162
 TI    A new approach to the limiting dilution assay.
 DT    9410
 AU    Balch AH; Hitchcock MJ; Brockwell PJ; Bristol-Myers Squibb, PRI,
       Wallingford, Connecticut.
 SO    J Biopharm Stat. 1994 Mar;4(1):101-12. Unique Identifier : AIDSLINE
       MED/94290523
 AB    Improved methods of human immunodeficiency virus isolation have sparked
       an increased interest in determination of the number and proportion of
       infected cells in plasma samples. The limiting dilution assay is a
       popular method of determining the proportion of infected cells. We
       propose a new estimator of the proportion of infected cells based on an
       underlying Markov chain model for the progression of infected cells to
       further flasks in the series. This method should improve both design and
       analyses of these assays.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/*MICROBIOLOGY  Colony Count,
       Microbial/METHODS  Comparative Study  Human  HIV/*GROWTH & DEVELOPMENT
       *Markov Chains  Reproducibility of Results  JOURNAL ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).