Document 0190
 DOCN  M9480190
 TI    Fetal immunological and haematological changes in intrauterine
       infection.
 DT    9410
 AU    Thilaganathan B; Carroll SG; Plachouras N; Makrydimas G; Nicolaides KH;
       Harris Birthright Research Centre for Fetal Medicine, King's; College
       Hospital School of Medicine, London, UK.
 SO    Br J Obstet Gynaecol. 1994 May;101(5):418-21. Unique Identifier :
       AIDSLINE MED/94289360
 AB    OBJECTIVE: To study fetal immunological and haematological changes to
       intrauterine infection. DESIGN: In 37 pregnancies at risk of
       intrauterine infection, fetal blood obtained by cordocentesis at 20 to
       36 weeks gestation was used for differential leucocyte counts, platelet
       count, enumeration of lymphocyte subpopulations, and neutrophil adhesion
       receptor expression. SETTING: Harris Birthright Research Centre for
       Fetal Medicine, London. RESULTS: All four fetuses with viral infections
       had platelet counts below the 5th centile and three had natural killer
       (NK) cell counts greater than the 95th centile of the normal range.
       Similarly, all five fetuses with bacterial or candidal infection had
       neutrophil counts greater than the 95th centile of the normal range;
       lymphocyte subpopulations were normal. CONCLUSIONS: In pregnancies
       complicated by intrauterine infection, fetuses exhibit NK cell
       lymphocytosis and thrombocytopenia in response to viraemia, and
       neutrophilia in response to bacteraemia from at least 21 weeks
       gestation.
 DE    Bacterial Infections/BLOOD/*IMMUNOLOGY  CD4-CD8 Ratio  Female  Fetal
       Blood  Fetal Diseases/BLOOD/*IMMUNOLOGY  Human  Killer Cells,
       Natural/*IMMUNOLOGY  Leukocyte Count  Neutropenia/ETIOLOGY  Platelet
       Count  Pregnancy  Pregnancy Complications, Infectious/*IMMUNOLOGY
       Support, Non-U.S. Gov't  Thrombocytopenia/ETIOLOGY  Virus
       Diseases/BLOOD/*IMMUNOLOGY  JOURNAL ARTICLE

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