Document 0217
 DOCN  M9480217
 TI    Adverse effects and drug interactions of clinical importance with
       antiviral drugs.
 DT    9410
 AU    Morris DJ; Department of Pathological Sciences, Medical School,
       Manchester,; England.
 SO    Drug Saf. 1994 Apr;10(4):281-91. Unique Identifier : AIDSLINE
       MED/94288920
 AB    Most antiviral drugs are nucleoside analogues with potential
       teratogenic, embryotoxic, carcinogenic and antiproliferative activities.
       They must be administered with caution during pregnancy, because some
       are known teratogens (e.g. amantadine) and a similar propensity cannot
       be entirely excluded for others (e.g. aciclovir). Their adverse effects
       mostly involve bone marrow depression (e.g. granulocytopenia with
       ganciclovir, anaemia with zidovudine) or neurotoxicity (e.g. seizures
       with interferon-alpha, peripheral neuropathy with zalcitabine), although
       gastrointestinal effects are also seen. Idiosyncratic reactions include
       didanosine-induced acute pancreatitis. Only inosine pranobex is largely
       free from toxicity. Idoxuridine must be administered topically, given
       the severity of its systemic adverse effects. Drug interactions
       involving antiviral agents mostly reflect shared toxicity with other
       agents (e.g. neutropenia with ganciclovir and zidovudine, pancreatitis
       with didanosine and alcohol), although renal excretion or hepatic
       metabolism may be implicated. Given the possibility of severe adverse
       reactions and drug interactions, antiviral chemotherapy should only be
       used for potentially serious virus infections. Topical administration
       avoids systemic adverse effects but not mutagenic risks, and may result
       in exposure of individuals other than the patient (e.g. aerosolised
       ribavirin).
 DE    Acyclovir/ADVERSE EFFECTS  Amantadine/ADVERSE EFFECTS  Antiviral
       Agents/*ADVERSE EFFECTS  AIDS-Related Opportunistic Infections/DRUG
       THERAPY  Didanosine/ADVERSE EFFECTS  Drug Interactions
       Foscarnet/ADVERSE EFFECTS  Ganciclovir/ADVERSE EFFECTS  Human
       Interferon-alpha/ADVERSE EFFECTS  Ribavirin/ADVERSE EFFECTS
       Rimantadine/ADVERSE EFFECTS  Vidarabine/ADVERSE EFFECTS
       Zalcitabine/ADVERSE EFFECTS  Zidovudine/ADVERSE EFFECTS  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).