Document 0451
 DOCN  M9480451
 TI    Human T cell lymphotropic virus type 1 in Zimbabwe.
 DT    9410
 AU    Houston S; Thornton C; Emmanuel J; Latif A; University of Zimbabwe
       Medical School, Avondale, Harare.
 SO    Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):170-2. Unique Identifier :
       AIDSLINE MED/94310624
 AB    Human T cell lymphotrophic virus type 1 (HTLV-1) causes myelopathy and
       adult T cell leukaemia. Knowledge of its distribution in Africa is
       limited. We performed HTLV-1 testing by enzyme immunoassay, with
       immunofluorescence assay confirmation, on 931 blood donors, 88 human
       immunodeficiency virus (HIV) seronegative patients with clinical
       features of acquired immune deficiency syndrome, 23 multi-transfused
       haemophiliacs, 8 patients with haematological malignancies, and 32
       patients with neurological disease. One blood donor and 3 neurological
       patients, all 3 with spinal cord syndromes, were HTLV-1-seropositive.
       Two of the 3 HTLV-1-positive myelopathy patients were co-infected with
       HIV and both experienced unusually rapid progression of neurological
       disease. HTLV-1 is uncommon but can be associated with myelopathy in
       Zimbabwe.
 DE    Adult  Blood Donors  Case Report  Enzyme-Linked Immunosorbent Assay
       Female  Fluorescent Antibody Technique  Human  HTLV-I/*ISOLATION & PURIF
       HTLV-I Infections/BLOOD/*EPIDEMIOLOGY  Male  Middle Age  Paraparesis,
       Tropical Spastic/EPIDEMIOLOGY  Prevalence  Support, Non-U.S. Gov't
       Zimbabwe/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).