Document 0489
 DOCN  M9480489
 TI    A CD30-positive T cell line established from an aggressive anaplastic
       large cell lymphoma, originally diagnosed as Hodgkin's disease.
 DT    9410
 AU    del Mistro A; Leszl A; Bertorelle R; Calabro ML; Panozzo M; Menin C;
       D'Andrea E; Chieco-Bianchi L; Istituto di Oncologia, CIRC, Universita di
       Padova, Italy.
 SO    Leukemia. 1994 Jul;8(7):1214-9. Unique Identifier : AIDSLINE
       MED/94309307
 AB    Ten months following the diagnosis of Hodgkin's disease (HD), a
       46-year-old woman presented cutaneous and leukemic involvement by CD30+
       anaplastic large cells, from which a continuously growing, exogenous
       growth factor-independent T cell line was established. The cultured
       cells are phenotypically and genotypically T cell in type, negative for
       EBV, HTLV-I and HTLV-II viral sequences, and release soluble CD30 into
       the supernatant. Karyotype analysis disclosed several chromosomal
       abnormalities, but none on chromosome 5q. The involvement of the short
       arm of chromosome 17 prompted us to investigate the TP53 gene by means
       of the polymerase chain reaction single-strand conformation polymorphism
       (PCR-SSCP) analysis, but no alterations were found in exons 5-8.
 DE    Antigens, CD30/*BIOSYNTHESIS  Case Report  DNA, Viral/ANALYSIS  Exons
       Female  Genes, p53  Genotype  Herpesvirus 4, Human/GENETICS  Hodgkin's
       Disease/*DIAGNOSIS/MICROBIOLOGY/*PATHOLOGY  Human  HTLV-I/GENETICS
       HTLV-II/GENETICS  Karyotyping  Lymphoma,
       Large-Cell/*DIAGNOSIS/MICROBIOLOGY/*PATHOLOGY  Middle Age  Phenotype
       Solubility  Support, Non-U.S. Gov't  T-Lymphocytes/*CYTOLOGY  *Tumor
       Cells, Cultured/MICROBIOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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