Document 0495
 DOCN  M9480495
 TI    Spatial discontinuities in human immunodeficiency virus type 1
       quasispecies derived from epidermal Langerhans cells of a patient with
       AIDS and evidence for double infection.
 DT    9410
 AU    Sala M; Zambruno G; Vartanian JP; Marconi A; Bertazzoni U; Wain-Hobson
       S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris,;
       France.
 SO    J Virol. 1994 Aug;68(8):5280-3. Unique Identifier : AIDSLINE
       MED/94309197
 AB    A nonhomogeneous spatial distribution of human immunodeficiency virus
       type 1 quasispecies was observed for epidermal Langerhans cells purified
       from skin patches taken from a patient with AIDS soon after death. Each
       patch presented a unique collection of sequences, distinct from those of
       juxtaposed patches or those derived from the other leg. Infection of
       Langerhans cells by virus from underlying T cells in the dermis might
       explain this partition. The analysis revealed the presence of two
       distinct cocirculating viral strains, indicating double infection.
 DE    Acquired Immunodeficiency Syndrome/*MICROBIOLOGY  Amino Acid Sequence
       Base Sequence  DNA, Viral  Human
       HIV-1/*CLASSIFICATION/GENETICS/ISOLATION & PURIF  Islets of
       Langerhans/*MICROBIOLOGY  Molecular Sequence Data  Sequence Homology,
       Amino Acid  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).