Document 0519
 DOCN  M9480519
 TI    Bacille Calmette-Guerin immunization in normal healthy adults.
 DT    9410
 AU    Brewer MA; Edwards KM; Palmer PS; Hinson HP; Department of Pediatrics,
       Vanderbilt University School of; Medicine, Nashville, Tennessee.
 SO    J Infect Dis. 1994 Aug;170(2):476-9. Unique Identifier : AIDSLINE
       MED/94308625
 AB    Bacille Calmette-Guerin (BCG) vaccine was administered to 20 purified
       protein derivative (PPD) skin test-negative and human immunodeficiency
       virus serology-negative, healthy adults 18-65 years old. Local adverse
       reactions were monitored and intermediate-strength PPD skin test
       responses were evaluated 2 months and 1 year after vaccination. All
       vaccinees developed erythema, induration, and tenderness at the
       vaccination site. Muscular soreness was reported by 15 subjects, local
       ulceration with drainage by 14, and tender regional adenopathy by 2. BCG
       organisms were isolated from the ulcer of the only vaccinee who was
       cultured. PPD skin tests revealed induration in all subjects. Normal
       healthy adults at risk of occupational exposure to tuberculosis and
       considering BCG immunization should be fully informed about the local
       reactions seen after BCG administration and the high rate of persistent
       PPD skin test responses. Since viable organisms can be recovered from
       ulcer drainage, vaccination sites should be covered to reduce nosocomial
       transmission of the vaccine strain.
 DE    Adult  *BCG Vaccine/ADVERSE EFFECTS/IMMUNOLOGY  Female  Human  Male
       Middle Age  Mycobacterium bovis/ISOLATION & PURIF  Prospective Studies
       Skin Diseases/MICROBIOLOGY  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  Tuberculin Test  Ulcer/MICROBIOLOGY  JOURNAL ARTICLE

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