Document 0523
 DOCN  M9480523
 TI    Environmental risk factors for acquisition of Mycobacterium avium
       complex in persons with human immunodeficiency virus infection.
 DT    9410
 AU    Horsburgh CR Jr; Chin DP; Yajko DM; Hopewell PC; Nassos PS; Elkin EP;
       Hadley WK; Stone EN; Simon EM; Gonzalez P; et al; Division of HIV/AIDS,
       Centers for Disease Control and Prevention,; Atlanta, Georgia 30333.
 SO    J Infect Dis. 1994 Aug;170(2):362-7. Unique Identifier : AIDSLINE
       MED/94308603
 AB    A case-control study was done to determine risk factors for
       Mycobacterium avium complex (MAC) disease in persons infected with human
       immunodeficiency virus (HIV) with < 50 CD4+ cells/mm3. In univariate
       analysis, cases (n = 83) had lower CD4+ cell counts than controls (n =
       177) (median, 10 vs. 17/mm3; P < .001) and were more likely to have
       consumed hard cheese (odds ratio [OR], 5.44; 95% confidence interval
       [CI], 1.61-18.4) but were less likely to have taken daily showers (OR,
       0.55; 95% CI, 0.33-0.94). In multivariate analysis, CD4+ cell count <
       25/mm3 (OR, 3.58; 95% CI, 1.71-7.49) and consumption of hard cheese (OR,
       5.63; 95% CI, 1.58-20.1) remained associated with disease, while daily
       showering (OR, 0.58; 95% CI, 0.28-0.88) remained protective. Increased
       risk for MAC disease in persons with HIV infection and low CD4+ cell
       counts is not associated with exposure to water or a variety of other
       environmental sources but may be associated with consumption of hard
       cheese.
 DE    Adult  AIDS-Related Opportunistic Infections/EPIDEMIOLOGY/*ETIOLOGY
       Bacteremia/EPIDEMIOLOGY/ETIOLOGY  Baths  Case-Control Studies  Cheese
       Feces/MICROBIOLOGY  Female  Food Microbiology  Human  Leukocyte Count
       Male  Mycobacterium avium Complex/ISOLATION & PURIF  Mycobacterium
       avium-intracellulare Infection/EPIDEMIOLOGY/  *ETIOLOGY  Risk Factors
       Sputum/MICROBIOLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  T4 Lymphocytes  Water Microbiology  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).