Document 0528
 DOCN  M9480528
 TI    Association between anti-human immunodeficiency virus type 1 (HIV-1)
       antibody-dependent cellular cytotoxicity antibody titers at birth and
       vertical transmission of HIV-1.
 DT    9410
 AU    Jenkins M; Landers D; Williams-Herman D; Wara D; Viscarello RR; Hammill
       HA; Kline MW; Shearer WT; Charlebois ED; Kohl S; Department of
       Pediatrics, University of California, San; Francisco.
 SO    J Infect Dis. 1994 Aug;170(2):308-12. Unique Identifier : AIDSLINE
       MED/94308594
 AB    Because vertical transmission of human immunodeficiency virus type 1
       (HIV-1) from mother to infant occurs in only 15%-35% of possible
       opportunities, natural immune defenses of the mother, fetus, or neonate
       may be protective against infection. The relation between
       antibody-dependent cellular cytotoxicity (ADCC) antibodies and HIV-1
       infection was explored in 78 neonates born to HIV-infected women. More
       than 90% of sera had measurable ADCC titers against HIV-1IIIB. Infant
       titers were closely correlated with maternal titers but were independent
       of total IgG and total antibody reactive to the same strain in whole
       virus ELISA. At birth, mean ADCC antibody levels of infants or their
       mothers were the same for infants who were infected and those who
       ultimately seroreverted and remained healthy. ADCC antibody titers
       against HIV-1SF2 were weakly correlated with anti-HIV-1IIIB titers and
       did not predict protection from HIV-1 infection. High levels of
       anti-HIV-1 ADCC antibody at birth are not protective against vertical
       transmission of HIV-1.
 DE    *Antibody-Dependent Cell Cytotoxicity  Antiviral Agents/THERAPEUTIC USE
       Cohort Studies  Enzyme-Linked Immunosorbent Assay  Female  Fetal
       Blood/IMMUNOLOGY  Human  HIV Antibodies/*BLOOD  HIV Infections/DRUG
       THERAPY/IMMUNOLOGY/*TRANSMISSION  HIV-1/*IMMUNOLOGY  Immunity,
       Maternally-Acquired  Infant, Newborn  Pregnancy  *Pregnancy
       Complications, Infectious/DRUG THERAPY/IMMUNOLOGY  Prospective Studies
       Retrospective Studies  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).