Document 0531 DOCN M9480531 TI Pathogenesis of pediatric human immunodeficiency virus type 1 infection. DT 9410 AU Wilfert CM; Wilson C; Luzuriaga K; Epstein L; Duke University Medical Center, Durham, NC 27710. SO J Infect Dis. 1994 Aug;170(2):286-92. Unique Identifier : AIDSLINE MED/94308591 AB This discussion of the pathogenesis of infant human immunodeficiency virus (HIV) type 1 infection emphasizes features unique to pediatric disease and provides general insights into HIV illness in all populations. Therapies designed to interrupt transmission of HIV can be most efficiently addressed through studies of maternal-infant transmission. The rapid progression of disease in children constantly emphasizes the urgent need for continued progress in treatment of HIV infection and presents a unique opportunity optimally to assess effects of early intervention. DE Adult AIDS Dementia Complex/ETIOLOGY Brain/MICROBIOLOGY Breast Feeding Female Human HIV Infections/*ETIOLOGY/TRANSMISSION *HIV-1/IMMUNOLOGY/PHYSIOLOGY Immune System/EMBRYOLOGY/MICROBIOLOGY Infant Infant, Newborn Pregnancy *Pregnancy Complications, Infectious Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes, Cytotoxic/IMMUNOLOGY Time Factors Virus Replication JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL SOURCE: National Library of Medicine. NOTICE: This material may be protected by Copyright Law (Title 17, U.S.Code).