Document 0541
 DOCN  M9480541
 TI    The use of methotrexate for treatment of psoriasis in patients with HIV
       infection.
 DT    9410
 AU    Maurer TA; Zackheim HS; Tuffanelli L; Berger TG; Department of
       Dermatology, University of San Francisco, CA.
 SO    J Am Acad Dermatol. 1994 Aug;31(2 Pt 2):372-5. Unique Identifier :
       AIDSLINE MED/94308359
 AB    The use of methotrexate (MTX) has been contraindicated for treatment of
       severe psoriasis in HIV infection on the basis of six previously
       reported cases in which MTX appeared to potentiate opportunistic
       infections and accelerate HIV disease. We describe three HIV-infected
       patients who were given MTX for severe psoriatic arthritis. In two
       patients opportunistic infections did not develop. On the basis of
       survival data, it is not clear that use of MTX adversely affected the
       natural course of their HIV disease.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Adult  Arthritis,
       Psoriatic/COMPLICATIONS/*DRUG THERAPY  AIDS-Related Opportunistic
       Infections/CHEMICALLY INDUCED  Case Report  Human  HIV
       Infections/*COMPLICATIONS  Male  Methotrexate/ADVERSE
       EFFECTS/CONTRAINDICATIONS/*THERAPEUTIC USE  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

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