Document 0572
 DOCN  M9480572
 TI    Mycobacterium avium infection in HIV-1-infected subjects increases
       monokine secretion and is associated with enhanced viral load and
       diminished immune response to viral antigens.
 DT    9410
 AU    Denis M; Ghadirian E; Pulmonary Research Unit, Faculty of Medicine,
       University of; Sherbrooke, Canada.
 SO    Clin Exp Immunol. 1994 Jul;97(1):76-82. Unique Identifier : AIDSLINE
       MED/94306756
 AB    The complex interaction between HIV-1 infection and Mycobacterium avium
       was studied. Viral burden was assessed, as well as immune response to
       HIV-1 in the context of Myco. avium infections. We also examined serum
       cytokine levels and cytokine release by blood mononuclear cells in
       HIV-1-infected subjects, infected or not with Myco. avium. Undetectable
       serum levels of IL-1, tumour necrosis factor-alpha (TNF-alpha) and IL-6
       were found in normal controls and in groups I, II and III of
       HIV-1-infected subjects. Moderate levels of TNF-alpha, IL-1 and IL-6
       were found in the sera of group IV patients. When group IV was
       subdivided into subjects with and without Myco. avium infections,
       subjects with Myco, avium infections were shown to have higher serum
       levels of TNF-alpha, IL-1 beta and IL-6 than those with other
       infections. Blood mononuclear cells from controls and HIV subjects were
       stimulated with bacterial lipopolysaccharide, and cytokine levels
       assessed. Cells from group II patients were shown to secrete normal
       levels of TNF-alpha and IL-6, and lower levels of IL-1 beta; group III
       subjects released higher levels of IL-6. Patients in group IV had blood
       cells that released elevated levels of IL-6 and TNF-alpha, and lower
       levels of IL-1 beta. Group IV subjects with Myco. avium infections had
       blood cells that released higher levels of TNF-alpha, IL-6 and IL-1 than
       group IV subjects with other infections. Assessment of viral burden in
       cells of HIV-1-infected subjects revealed that Myco. avium-infected
       subjects had a higher level of virus burden and a lower level of
       lymphoproliferative response to an inactivated gp120-depleted HIV-1
       antigen than AIDS subjects with other infections. These data suggest
       that Myco. avium infections in HIV-1-infected subjects hasten the
       progression of viral disease, enhance cytokine release and contribute to
       the anergy to viral antigens.
 DE    beta 2-Microglobulin/METABOLISM  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/*IMMUNOLOGY/  MICROBIOLOGY
       Cytokines/BLOOD/SECRETION  Human  HIV Antigens/IMMUNOLOGY  HIV Core
       Protein p24/BLOOD  *HIV-1/IMMUNOLOGY/ISOLATION & PURIF  Immunity,
       Cellular  In Vitro  Leukocytes, Mononuclear/IMMUNOLOGY  Lymphocyte
       Transformation  Monokines/*SECRETION  Mycobacterium avium-intracellulare
       Infection/*COMPLICATIONS/  *IMMUNOLOGY/MICROBIOLOGY  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

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