Document 0580
 DOCN  M9480580
 TI    The in vivo expression of cytokine genes in humans.
 DT    9410
 AU    Galanaud P; Unite d'Immunopathologie et Immunologie Virale de l'INSERM;
       (Unite 131), l'Association Claude Bernard, Universite de; Paris-Sud,
       Hopital Antoine Beclere, Clamart, France.
 SO    J Lipid Mediat Cell Signal. 1994 Feb;9(1):37-41. Unique Identifier :
       AIDSLINE MED/94305939
 AB    We used in situ hybridization to study the expression of interleukin
       genes in sarcoidosis and in persistent generalized lymphadenopathy of
       HIV disease. In both cases, we found a dramatic over-expression of the
       interferon-gamma (IFN-gamma) gene as compared to that of the
       interleukin-2 (IL-2) gene. In sarcoidosis, IFN-gamma producing cells are
       CD4 T cells and are associated with IL-1 beta gene expressing monocytic
       cells. In HIV lympadenopathy IFN-gamma producing cells are C8 T cells
       engaged in cytotoxic function, as demonstrated by the concomitant
       expression of serine esterase B gene. Thus distinct patterns of
       interleukin production can be defined in vivo in selected
       immunopathological situations.
 DE    Biopsy  Comparative Study  *Gene Expression  Human  HIV
       Seropositivity/*IMMUNOLOGY/METABOLISM/PATHOLOGY  Interferon Type
       II/*BIOSYNTHESIS/GENETICS  Interleukin-1/BIOSYNTHESIS/GENETICS
       Interleukin-2/BIOSYNTHESIS/GENETICS  Interleukin-6/BIOSYNTHESIS/GENETICS
       Interleukins/*BIOSYNTHESIS/GENETICS  Lymph
       Nodes/IMMUNOLOGY/*METABOLISM/PATHOLOGY  Reference Values
       Sarcoidosis/*IMMUNOLOGY/METABOLISM/PATHOLOGY  JOURNAL ARTICLE

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