Document 0651
 DOCN  M9480651
 TI    [Prevention of MAI infections in AIDS with Ansatipine: experience at a
       hospital. From an interview with Dr. Jean-Luc Meynard]
 DT    9410
 AU    Meynard JL; Service des Maladies Infectieuses et Tropicales du Pr
       Frottier,; Hopital Saint-Antoine, Paris.
 SO    Allerg Immunol (Paris). 1994 Apr;26(4):155-7. Unique Identifier :
       AIDSLINE MED/94304500
 AB    Nowadays, infections by the Mycobacterium avium complex (MAC) have
       become amongst the most frequent of the opportunistic bacterial
       infections in AIDS, following the introduction of prophylaxis to
       pneumocystosis and toxoplasmosis. MAC infections are recognised as a
       serious pathology that quickly causes hidden conditions then death of
       the patient after a short time and so there is need for an effective
       prophylaxis. In this context, rifabutine (Ansatipine) fills the
       therapeutic gap and is needed by both practitioners and patients who are
       affected by these serious infections. For several months, the AIDS
       committee of the Hopital Saint-Antoine in Paris has advised the
       systematic introduction of prophylactic treatment by Ansatipine, after
       proper prescriptive indications, for HIV patients both in hospital and
       in outside consultations. Retrospective analysis after 2 1/2 months of a
       population sample of 32 patients, mostly non hospitalised but followed
       by the Service of Infectious Diseases of the hospital and receiving
       Ansatipine, showed no documented infection by MAC in the patients whose
       quality of life was very satisfactory. Furthermore, the prophylactic
       treatment was well-tolerated without any withdrawals. Today,
       distribution of Ansatipine to town pharmacies can only improve the lives
       of patients and encourage practitioners to profit from a treatment of
       indisputable benefit.
 DE    AIDS-Related Opportunistic Infections/EPIDEMIOLOGY/MICROBIOLOGY/
       *PREVENTION & CONTROL  Drug Evaluation  English Abstract  Female
       Hospitals  Human  Male  Mycobacterium avium-intracellulare
       Infection/EPIDEMIOLOGY/  *PREVENTION & CONTROL  Retrospective Studies
       Rifabutin/*THERAPEUTIC USE  INTERVIEW  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).