Document 0840
 DOCN  M9480840
 TI    Evaluation of the Murex SUDS HIV-1 antibody test in a mixed population.
 DT    9410
 AU    Johnson JE; Ely DD; Overman SB; Goodman NL; University of Kentucky
       Medical Center, Lexington.
 SO    Abstr Gen Meet Am Soc Microbiol. 1994;94:554 (abstract no. C-364).
       Unique Identifier : AIDSLINE ASM94/94313105
 AB    Serum specimens from 304 patients and 116 blood donors were tested for
       HIV-1 antibody using the Murex SUDS HIV-1 and the Genetic Systems LAV
       EIA test systems. There were 320 specimens non-reactive with both SUDS
       and LAV (116 blood donor specimens and 204 patient specimens). There
       were 53 patient specimens which were reproducibly reactive by LAV and
       confirmed as positive by both Western blot (WB) and immunofluorescence
       (IFA). All 53 of these specimens were reactive by SUDS (100% sensitive).
       Of 47 specimens reproducibly reactive by LAV but unconfirmed by WB and
       IFA, the SUDS test was reactive in only 4 instances. The overall results
       of this study demonstrate that SUDS was 100% sensitive (53/53) and 98.9%
       specific (363/367) and indicate that the Murex SUDS HIV-1 antibody test
       system may be acceptable for rapid screening in specific situations.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*DIAGNOSIS/PREVENTION &
       CONTROL  *Blood Donors  Blotting, Western/METHODS  Comparative Study
       Fluorescent Antibody Technique  Human  HIV Antibodies/*BLOOD
       HIV-1/*ISOLATION & PURIF  Immunoenzyme Techniques  Mass
       Screening/METHODS  Reagent Kits, Diagnostic  Sensitivity and Specificity
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).