Document 0845
 DOCN  M9480845
 TI    Association of HEp-2 cell adherent Escherichia coli with diarrhea among
       adults infected with HIV.
 DT    9410
 AU    Mathewson JJ; Jiang ZD; Luo N; Chintu C; Zumla A; DuPont HL; University
       of Texas, Houston.
 SO    Abstr Gen Meet Am Soc Microbiol. 1994;94:544 (abstract no. C-303).
       Unique Identifier : AIDSLINE ASM94/94313100
 AB    Both acute and chronic diarrhea are common problems in African patients
       infected with the human immunodeficiency virus (HIV). There are many
       different agents responsible for diarrhea in this population, but a
       recognized cause is not found in most cases. We tested E. coli from
       Zambians for adherence to HEp-2 cells. Among the 99 HIV+ patients: there
       were 19 asymptomatic controls, 42 with acute diarrhea (< 72 hrs), and 38
       with chronic diarrhea (> 30 days). Among the 15 HIV-patients, there were
       3 asymptomatic controls and 6 with each acute and chronic diarrhea. E.
       coli that adhered to HEp-2 cells were the most common enteropathogen
       among the HIV+ patients with diarrhea. HEp-2 cell adherent E. coli were
       identified significantly more frequently from all HIV+ individuals than
       from the HIV-group (p < 0.01). Adherent E. coli were found more commonly
       among HIV+ patients with acute diarrhea, than among the HIV+
       asymptomatic controls (60% versus 37%) and significantly more often
       among HIV+ patients with chronic diarrhea (79%) compared to HIV+
       controls (p < 0.001). These organisms were also found significantly more
       often in HIV+ patients with chronic diarrhea than among HIV-patients
       with chronic diarrhea (p < 0.007). The different adherence patterns of
       the adherence of strains isolated from the AIDS patients varied. None of
       the locally adherent E. coli hybridized with the enteropathogenic E.
       coli adherence factor (EAF) probe. Adherent E. coli strains may explain
       a considerable portion of AIDS associated diarrhea in the African form
       of the disease and deserve further study.
 DE    Acute Disease  Adult  AIDS-Related Opportunistic
       Infections/*MICROBIOLOGY  *Bacterial Adhesion  Cell Line  Chronic
       Disease  Comparative Study  Diarrhea/EPIDEMIOLOGY/*MICROBIOLOGY
       Escherichia coli/ISOLATION & PURIF/*PHYSIOLOGY  Escherichia coli
       Infections/*MICROBIOLOGY/PHYSIOPATHOLOGY  Human  HIV Seronegativity
       *HIV Seropositivity  Tumor Cells, Cultured  MEETING ABSTRACT

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