Document 0854
 DOCN  M9480854
 TI    Immune and serologic profiles of HIV-infected and non-infected
       hemophilic children and adolescents. HGDS.
 DT    9410
 AU    Jason J; Murphy J; Sleeper LA; Donfield SM; Warrier I; Arkin S; Evatt B;
       Gomperts ED; CDC, Atlanta, GA.
 SO    Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-10). Unique
       Identifier : AIDSLINE ASM94/94313091
 AB    To assess relationships among HIV's effects on hemophilic children and
       adolescents' immunologic parameters and vaccine-related serology, we
       analyzed extensive baseline immunologic evaluations of 207 HIV
       antibody-positive (HIV+) and 126 HIV antibody-negative (HIV-) hemophilic
       children and adolescents. All group comparisons were age-adjusted. HIV+,
       compared to HIV-, participants had lower CD4+ lymphocyte counts
       (medians: HIV+ 423/microliters, HIV- 895/microliters; p < .0001), NK
       cell counts (medians: HIV+ 109/microliters, HIV- 210/microliters; p <
       .0001), and CD19+ lymphocyte counts (medians: HIV+ 229/microliters, HIV-
       387/microliters; p < .0001). The HIV+ participants also had higher CD8+
       lymphocyte counts (medians: HIV+ 841/microliters, HIV- 678/microliters;
       p = .001) and serum immunoglobulin levels (IgG 1788 vs 1232 mg/dL, p <
       .0001; IgA 219 vs 156 mg/dL, p < .0001; IgM 141 vs 114 mg/dL, p = .0199.
       Seroprevalence rates for diphtheria toxoid, measles, and mumps antigens
       were significantly lower in the HIV+ group compared to the HIV- group.
       IgG levels, IgM levels, and serologic titers to vaccine antigens showed
       little correlation with T cell parameters. HIV had significant, largely
       independent T- and B-lymphocyte effects on this pediatric cohort. The
       effects of HIV on infected hemophilic youth in this study are severe,
       broad, and not necessarily all secondary to infection of CD4+
       lymphocytes. Our results support additional, independent effects on
       B-lymphocytes, antigen presenting cells, and/or cytokine production.
 DE    Adolescence  Antigens, CD/BLOOD  Antigens, Differentiation,
       B-Lymphocyte/BLOOD  Antigens, Viral/BLOOD  B-Lymphocytes/IMMUNOLOGY
       Child  Cohort Studies  Comparative Study
       Hemophilia/BLOOD/COMPLICATIONS/*IMMUNOLOGY  Human  HIV
       Infections/BLOOD/COMPLICATIONS/*IMMUNOLOGY  HIV Seronegativity  HIV
       Seropositivity/BLOOD/*IMMUNOLOGY  IgG/BLOOD  IgM/BLOOD  Killer Cells,
       Natural/IMMUNOLOGY  Lymphocytes/*IMMUNOLOGY  T-Lymphocytes/IMMUNOLOGY
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).