Document 0016
 DOCN  M9490016
 TI    The resurgence of tuberculosis.
 DT    9411
 AU    Young LS; Wormser GP; Kuzell Institute for Arthritis and Infectious
       Diseases,; California Pacific Medical Center, San Francisco 94115.
 SO    Scand J Infect Dis Suppl. 1994;93:9-19. Unique Identifier : AIDSLINE
       MED/94323730
 AB    The resurgence of tuberculosis has been documented in both developed and
       developing countries and is associated with the spread of human
       immunodeficiency virus (HIV) infection. In the USA, the steady decline
       in the incidence of tuberculosis witnessed during the past three decades
       has halted, and since early 1986, a resurgence of tuberculosis has been
       noted. A similar change in trend has occurred in the West, for example
       Britain and continental Europe. The present problem is aggravated by the
       emergence of multiply drug resistant (MDR) strains of Mycobacterium
       tuberculosis. While drug resistance is not a new phenomenon, it had not
       hitherto been experienced in combination with HIV infection. Previously,
       MDR tuberculosis was indolent, slowly progressive and usually restricted
       to the lungs. However, in the setting of an HIV-infected patient it is
       often systemic, aggressive, difficult to treat and associated with early
       mortality. In New York State, many of the population 'at risk' of
       contracting tuberculosis, as well as of HIV infection have been
       incarcerated. This provides a public health opportunity to intervene to
       prevent and treat both of these diseases.
 DE    Antitubercular Agents/THERAPEUTIC USE  Human  HIV
       Infections/COMPLICATIONS  Prevalence  Prisons/STATISTICS & NUMER DATA
       *Tuberculosis, Multidrug-Resistant/COMPLICATIONS/DRUG THERAPY/
       EPIDEMIOLOGY  World Health  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).