Document 0019
 DOCN  M9490019
 TI    Smoothing grouped bivariate data to obtain the incubation period
       distribution of AIDS.
 DT    9411
 AU    Taylor JM; Chon Y; Department of Biostatistics, UCLA School of Public
       Health 90024.
 SO    Stat Med. 1994 May 15;13(9):969-81. Unique Identifier : AIDSLINE
       MED/94323614
 AB    We use a penalized likelihood approach to obtain a smooth estimate of a
       bivariate distribution from grouped data where each observation consists
       of a region in a plane. The purpose of the analysis is to estimate the
       incubation period distribution of AIDS from the Multicenter AIDS Cohort
       Study, a prevalent cohort of homosexual men. In this article we
       illustrate the usefulness of the penalized likelihood approach. We also
       discuss the use of a cross-validation and a Bayesian scheme to choose
       the smoothing parameters and bootstrap samples to assess uncertainty.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY/TRANSMISSION  AIDS
       Serodiagnosis/STATISTICS & NUMER DATA  *Cohort Studies  Confidence
       Intervals  Disease Outbreaks/*STATISTICS & NUMER DATA  Follow-Up Studies
       Homosexuality  Human  Los Angeles  Male  *Models, Statistical
       Multicenter Studies/*STATISTICS & NUMER DATA  Reproducibility of Results
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).