Document 0025
 DOCN  M9490025
 TI    Carbon monoxide-diffusing capacity in intravenous drug abusers: the
       effect of cigarette smoking and HIV infection.
 DT    9411
 AU    Foresti V; Villa A; De Filippi G; Numeroso R; III Divisione di Medicina
       Generale, Ospedale Fatebenefratelli,; Milano.
 SO    Recenti Prog Med. 1994 Jun;85(6):323-7. Unique Identifier : AIDSLINE
       MED/94323527
 AB    A reduction in the Dco has been frequently found in intravenous drug
       addicts (IVDAs) and in subjects with HIV infection. Since also cigarette
       smoking decreases Dco, we studied a group of street IVDAs, who did not
       show respiratory symptoms and/or infiltrates on chest x-ray film.
       Sixty-two patients were presently smoking, 2 had never smoked.
       Twenty-seven were HIV-negative and 37 HIV-positive. Mean values for Dco
       (percent of predicted values) were 78 +/- 16.4 in HIV-positives compared
       to 97.9 +/- 17.6 in HIV-negatives (p < 0.0001) using smoking specific
       equations and 71.8 +/- 15.4 in HIV-positives compared to 80.7 +/- 13.4
       (p < 0.0001) using non-smokers equations. Dco was < 80 percent in 19 of
       35 (54.3%) HIV-positive subjects and in 4 of 26 (15.4%) HIV-negative
       subjects (p < 0.009) using predicted values for smokers, and in 28 of 35
       (80%) HIV-positive subjects and in 6 of 26 (23.1%) HIV-negative subjects
       (p < 0.0001) using predicted values for non-smokers. These data suggest
       that Dco alterations observed in HIV-positive subjects are due, in
       absence of respiratory symptoms and/or chest x-ray abnormalities, to an
       interstitial pneumopathy due to HIV or to a subclinical pulmonary
       disease. We conclude that the knowing of smoking in IVDAs is useful, but
       the knowing of seropositivity is much more important, since a marked
       reduction of Dco in these subjects suggests an HIV-related lymphocytic
       alveolitis, an opportunistic infection or a malignancy.
 DE    Adolescence  Adult  *Carbon Monoxide  Comparative Study  Female  Human
       HIV Infections/*PHYSIOPATHOLOGY  HIV Seronegativity/PHYSIOLOGY  HIV
       Seropositivity/PHYSIOPATHOLOGY  *HIV-1/IMMUNOLOGY  Male  *Narcotics
       Prospective Studies  *Pulmonary Diffusing Capacity
       Smoking/*PHYSIOPATHOLOGY  *Street Drugs  Substance Abuse,
       Intravenous/*PHYSIOPATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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