Document 0051
 DOCN  M9490051
 TI    [Immunological findings of bronchoalveolar lavage fluid (BALF) in
       sarcoidosis; analysis of soluble CD4 molecule and soluble CD8 molecule]
 DT    9411
 AU    Sato S; Second Department of Internal Medicine, Nagoya City University;
       Medical School.
 SO    Nippon Rinsho. 1994 Jun;52(6):1550-5. Unique Identifier : AIDSLINE
       MED/94322483
 AB    Since the introduction of bronchoalveolar lavage (BAL) by Reynolds and
       Newball in 1974, this procedure has been used to characterize the
       cellular and soluble components of alveolar lining fluid in many
       interstitial lung diseases. We reviewed BAL fluid findings of clinical
       and pathophysiologic researches in patients with pulmonary sarcoidosis.
       Moreover, our recent data about soluble CD4 molecule (sCD4) and soluble
       CD8 molecule (sCD8) were also described. The sarcoidosis patients had
       the significantly higher level of sCD4 in BAL fluid compared with normal
       subjects. The level of sCD8 in serum in active sarcoidosis was
       significantly higher than that in normal subjects. Furthermore,
       significant correlation between the levels of serum sCD8 and ACE was
       observed in sarcoidosis.
 DE    Adult  Antigens, CD4/*ANALYSIS  Antigens, CD8/*ANALYSIS  Bronchoalveolar
       Lavage Fluid/*IMMUNOLOGY  CD4-CD8 Ratio  English Abstract  Female  Human
       Male  Prognosis  Sarcoidosis, Pulmonary/*IMMUNOLOGY  Smoking  Solubility
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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