Document 0058
 DOCN  M9490058
 TI    The effect of nebulised pentamidine on the concentration of intra-oral
       Candida albicans in HIV-infected patients.
 DT    9411
 AU    Nolan A; Lamey PJ; MacFarlane TW; Aitchison TC; Shaw J; Sirel JY;
       Department of Oral Medicine, Eastman Dental Hospital, London.
 SO    J Med Microbiol. 1994 Aug;41(2):95-7. Unique Identifier : AIDSLINE
       MED/94322377
 AB    This prospective study investigated whether oral candidal carriage in
       HIV-infected patients was altered by pentamidine therapy. Repeated oral
       rinses were taken from 56 HIV-positive patients over a 2-year period.
       Oral candidal carriage was investigated in two groups of patients, one
       receiving prophylactic pentamidine therapy and the other not receiving
       regular prophylaxis. Patients receiving pentamidine had lower
       concentrations of Candida albicans intra-orally than patients who did
       not receive it. Furthermore, patients who received pentamidine at one
       stage of the study, but not another, also had lower concentrations of C.
       albicans intra-orally when receiving pentamidine. These findings
       indicate that pentamidine is useful as a local agent for prophylaxis
       against intra-oral candidosis in HIV-infected patients.
 DE    Administration, Inhalation  Adult  Aerosols  Candida albicans/*DRUG
       EFFECTS/ISOLATION & PURIF  Candidiasis, Oral/*PREVENTION & CONTROL
       Carrier State/*PREVENTION & CONTROL  Female  Follow-Up Studies  Human
       HIV Infections/*COMPLICATIONS  Male  Middle Age  Mouth
       Mucosa/MICROBIOLOGY  Pentamidine/ADMINISTRATION &
       DOSAGE/PHARMACOLOGY/*THERAPEUTIC USE  Prospective Studies  CLINICAL
       TRIAL  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).