Document 0059
 DOCN  M9490059
 TI    Significance of oral examination in chronic graft-versus-host disease.
 DT    9411
 AU    Hiroki A; Nakamura S; Shinohara M; Oka M; Second Department of Oral and
       Maxillofacial Surgery, Kyushu; University, Fukuoka, Japan.
 SO    J Oral Pathol Med. 1994 May;23(5):209-15. Unique Identifier : AIDSLINE
       MED/94322283
 AB    Fourteen patients who received allogeneic bone marrow transplantation
       (BMT) were examined 100 to 220 days after BMT. Ten out of 14 patients
       were diagnosed as having chronic graft-versus-host disease (cGVHD) in
       skin, liver, eyes and other organs. These cGVHD patients also had
       objective evidence of oral involvement. Subjective xerostomia was
       experienced by 7 cGVHD patients and decreased whole saliva flow was
       observed in 4 cGVHD patients. However, no patient had a history of
       parotid swelling or notable abnormality in parotid sialography. Labial
       salivary glands (LSG) or 9 cGVHD patients showed atrophy and/or
       destruction in association with diffusely infiltrating lymphocytes. The
       infiltrating lymphocytes were mainly CD3+ T cells with a predominance of
       CD8+ cells over CD4+ cells. Lichenoid lesions on the oral mucosa were
       also observed in 5 cGVHD patients. Thus, thus study indicated that oral
       examination, including LSG biopsy, is useful in the diagnosis of cGVHD.
 DE    Adolescence  Adult  Bone Marrow Transplantation/ADVERSE EFFECTS  Chronic
       Disease  CD4-CD8 Ratio  Female  Graft vs Host
       Disease/*DIAGNOSIS/ETIOLOGY  Human  Lichenoid Eruptions  Male  Middle
       Age  Mouth Diseases/*DIAGNOSIS/ETIOLOGY  Mouth Mucosa/PATHOLOGY
       Support, Non-U.S. Gov't  Xerostomia/*DIAGNOSIS  JOURNAL ARTICLE

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