Document 0125
 DOCN  M9490125
 TI    [Effect of synthetic fragments of immunodominant regions of HIV viral
       proteins on the oxygen metabolism of human neutrophils]
 DT    9411
 AU    Zemskov VM; Drukh VM; Subbotin SM; Andreev SM; Sidorova MV; Vafina MG;
       Tsvetkov DE; Vorob'ev AA
 SO    Biull Eksp Biol Med. 1993 Feb;115(2):185-7. Unique Identifier : AIDSLINE
       MED/94318879
 AB    Influence of synthetic peptides identical to fragments of natural human
       immunodeficiency virus (HIV) glycoproteins gp 120 and gp 41, on
       luminol-enhanced chemiluminescence (CL) of human neutrophils has been
       studied. It was established that some of peptide analogs of gp 120 and
       gp 41 immunodominant regions are able to suppress spontaneous CL: but
       when being used with dimethylsulfoxide they dramatically stimulate it
       and deteriorate opsonized zymosan-induced CL. Conclusions about the
       necessity of possible side effects considering during use of peptide
       vaccines against HIV have been made. It is also possible to explain some
       neutrophil dysfunction in HIV infected subjects as the result of HIV
       glycoproteins direct influence on this cells.
 DE    Acquired Immunodeficiency Syndrome/METABOLISM/PATHOLOGY
       Chemiluminescence  Dimethyl Sulfoxide/PHARMACOLOGY  English Abstract
       Human  HIV Envelope Protein gp120/*CHEMISTRY  HIV Envelope Protein
       gp41/*CHEMISTRY  Immunodominant Epitopes/*IMMUNOLOGY  Neutrophils/DRUG
       EFFECTS/IMMUNOLOGY/*METABOLISM  Oxygen/*METABOLISM  Respiratory Burst
       Zymosan/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).