Document 0502
 DOCN  M9490502
 TI    Pharmacodynamic relationship of pharmacokinetic parameters of
       maintenance doses of foscarnet and clinical outcome of cytomegalovirus
       retinitis.
 DT    9411
 AU    Jacobson MA; Polsky B; Causey D; Davis R; Tong W; O'Donnell JJ;
       Kuppermann BD; Heinemann MH; Feinberg J; Lizak P; et al; Department of
       Medicine, University of California, San Francisco.
 SO    Antimicrob Agents Chemother. 1994 May;38(5):1190-3. Unique Identifier :
       AIDSLINE MED/94346833
 AB    The pharmacodynamic relationship between a range of foscarnet exposure
       measurements obtained from studying nine patients receiving ongoing
       maintenance therapy for cytomegalovirus retinitis and a range of
       efficacy values (days to retinitis progression) obtained by independent
       examination of serial retinal photographs from the same nine patients
       was analyzed. In the resulting proportional hazards models, the
       foscarnet area under the concentration-time curve approached statistical
       significance (P = 0.11) as a predictor of decreased risk of retinitis
       progression.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Adolescence  Adult
       Aged  Chromatography, High Pressure Liquid  Cytomegalovirus
       Retinitis/*DRUG THERAPY/ETIOLOGY/MICROBIOLOGY  Electrochemistry
       Foscarnet/ADMINISTRATION & DOSAGE/*PHARMACOKINETICS/*THERAPEUTIC  USE
       Human  Infusions, Intravenous  Middle Age  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  Treatment Outcome  CLINICAL TRIAL  JOURNAL
       ARTICLE  RANDOMIZED CONTROLLED TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).