Document 0533
 DOCN  M9490533
 TI    Angiogenic process in bacillary angiomatosis.
 DT    9411
 AU    Kostianovsky M; Greco MA; Department of Pathology and Cell Biology,
       Thomas Jefferson; University, Philadelphia, Pennsylvania.
 SO    Ultrastruct Pathol. 1994 May-Jun;18(3):349-55. Unique Identifier :
       AIDSLINE MED/94345812
 AB    Eight cases of cutaneous bacillary angiomatosis related to acquired
       immunodeficiency syndrome were studied by light and electron microscopy
       and by immunohistochemistry with a panel of antibodies specific for
       endothelial and histiocytic markers. Light microscopy showed an
       inflammatory reaction with florid neovascularization and clusters of
       Warthin-Starry-positive bacilli. In addition, solid areas of spindle
       cells were also present that in some cases mimicked Kaposi's sarcoma or
       other sarcomas. The investigation focused primarily on the spindle cell
       areas and the angiogenic process present in bacillary angiomatosis. By
       immunohistochemistry the lesions, including the spindle cell areas,
       expressed all endothelial markers used; CD34, factor VIII-related
       antigen, and Ulex europaeus 1 were the most consistent in intensity,
       however. In those areas the other endothelial markers, BNH9 and
       Psophocarpus tetragonolobus, were weak and not always uniform. The
       macrophage/monocyte markers used were alpha 1-antitrypsin, lysosome, kp1
       (CD68), and polyclonal factor XIIIa; these revealed a sprinkle of
       positive cells ranging from 10% to 20% of the cell population. By
       electron microscopy primitive capillaries were present lined by plump
       endothelial cells containing frequent abluminal microprocesses forming
       intercellular lumina. Mitoses and intracytoplasmic lumen formation were
       infrequent. The study illustrates that bacillary angiomatosis is
       composed of active endothelial neoformation with the spindle cells
       representing immature endothelial cells. Furthermore, the features of
       this angiogenic process recapitulate the morphologic events described in
       experimental models.
 DE    Angiomatosis, Bacillary/MICROBIOLOGY/*PATHOLOGY
       Capillaries/ULTRASTRUCTURE  Human  HIV Infections/COMPLICATIONS
       Immunoenzyme Techniques  Male  Neovascularization/*MICROBIOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).