Document 0606
 DOCN  M9490606
 TI    Motor analysis predicts progression in HIV-associated brain disease.
 DT    9411
 AU    Arendt G; Hefter H; Hilperath F; von Giesen HJ; Strohmeyer G; Freund HJ;
       Department of Neurology, Heinrich Heine University, Dusseldorf,;
       Germany.
 SO    J Neurol Sci. 1994 May;123(1-2):180-5. Unique Identifier : AIDSLINE
       MED/94342931
 AB    One hundred HIV-positive individuals without clinically evident central
       nervous system (CNS) deficits entered this follow-up study and were
       examined clinically and with a well-defined motor test battery every 3
       months over 2 years or until they decreased. They underwent magnetic
       resonance tomography once a year. None received any form of therapy at
       onset of the study. Three groups were analyzed: (A) patients without
       electrophysiologically detectable motor impairment (n = 23), (B)
       patients with electrophysiologically detectable motor impairment but no
       virostatic medication (n = 33), and (C) patients with motor deficits
       undergoing AZT treatment (n = 44) after study onset. Group A patients,
       although slightly deteriorating over time, had the best clinical and
       electrophysiological outcome compared to the other groups, whereas group
       B patients deteriorated markedly in both clinical and
       electrophysiological tests, even though the majority did not develop
       cerebral complications during the observation period. Those group C
       patients belonging to early CDC stages (II and III) improved
       electrophysiologically under AZT therapy, while 76% of the patients in
       more advanced stages (CDC IVA-D) died of cerebral AIDS manifestations.
       Four patients of this group, being alive at the end of the study, were
       completely demented. It is suggested that early detectable motor
       impairment predicts future cerebral involvement in AIDS. Late onset of
       virostatic treatment did not influence the clinical outcome.
 DE    Adult  AIDS Dementia Complex/*PHYSIOPATHOLOGY  Comparative Study
       Electrophysiology/METHODS  Female  Follow-Up Studies  Human  HIV
       Seropositivity/DRUG THERAPY/*PHYSIOPATHOLOGY  Magnetic Resonance Imaging
       Male  *Motor Activity  *Neurologic Examination  Predictive Value of
       Tests  Prognosis  Time Factors  Tremor  Zidovudine/THERAPEUTIC USE
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).