Document 0637
 DOCN  M9490637
 TI    Prevalence of high serum and red cell ferritin levels in HIV-infected
       patients.
 DT    9411
 AU    Riera A; Gimferrer E; Cadafalch J; Remacha A; Martin S; Department of
       Internal Medicine, Hospital de Sant Pau,; Universitat Autonoma de
       Barcelona, Spain.
 SO    Haematologica. 1994 Mar-Apr;79(2):165-7. Unique Identifier : AIDSLINE
       MED/94341737
 AB    We report a high prevalence of elevated serum and red cell ferritin (SF
       and RCF) levels in 168 patients with HIV infection. SF levels increase
       with clinical worsening of infection and with decreasing CD4+ lymphocyte
       counts (ANOVA, p < 0.001) while RCF is significantly higher in
       asymptomatic AIDS patients (ANOVA, p < 0.001) and in those treated with
       zidovudine (AZT) (ANOVA, p < 0.001). It is suggested that, although
       inflammatory processes may explain high SF levels, if we also take in
       account RCF levels a possible association between iron overload and HIV
       infection might exist, and this may be worsened by AZT treatment. The
       significance of these high ferritin levels and their effects on immune
       system suppression and susceptibility to infectious and neoplastic
       complications in these patients merits further investigation.
 DE    Analysis of Variance  Biological Markers/BLOOD  Erythrocytes/*METABOLISM
       Ferritin/*BLOOD  Human  HIV Infections/*BLOOD  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

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