Document 0638
 DOCN  M9490638
 TI    Oral lesions among HIV-infected hemophiliacs. A study of 54 patients.
 DT    9411
 AU    Ficarra G; Chiodo M; Morfini M; Longo G; Orsi A; Piluso S; Rafanelli D;
       Institute of Odontology and Stomatology, University of Florence,; Italy.
 SO    Haematologica. 1994 Mar-Apr;79(2):148-53. Unique Identifier : AIDSLINE
       MED/94341735
 AB    BACKGROUND. HIV-infected individuals develop a large variety of oral
       manifestations. This study was designed to assess the prevalence and
       types of oral lesions among HIV-positive hemophiliacs. MATERIALS AND
       METHODS. A study population of 54 hemophiliacs was evaluated from
       February, 1987 to March, 1992 in order to analyze types, prevalence and
       relationships to clinical stages of HIV-related oral lesions. Thirty-six
       (67%) of the group of patients were HIV seropositive. The remaining 18
       tested negative to HIV during the observation period. RESULTS. The
       majority of patients suffered from hemophilia A. One patient was also
       bisexual and two were also intravenous drug abusers. Analysis of patient
       stage revealed that half had a CD4+ T-lymphocyte count over 0.5 x
       10(9)/L cells, 10 between 0.2 and 0.499 x 10(9)/L and 8 showed a count
       lower than 200 x 10(9)/L. Oral lesions were recorded in 18 (50%)
       HIV-seropositive hemophiliacs. No oral lesions were observed among the
       HIV-seronegative hemophiliacs. Advanced stage of immunosuppression and
       presence of oral lesions were significantly associated (p = 0.040).
       Candidiasis was the most common disturbance, followed by hairy
       leukoplakia. Oral herpes simplex infection, necrotizing gingivitis and
       facial herpes zoster were found in a small number of patients. Those
       with oral lesions showed a lower median CD4+ T lymphocyte count (0.209 x
       10(9)/L cells; range 0.008 to 0.615) when compared to the ones without
       oral lesions (median CD4+ count was 0.539 x 10(9)/L cells; range 0.042
       to 1.180; p = 0.002). CONCLUSIONS. HIV-seropositive hemophiliacs may
       develop oral lesions during the course of their disease. Candidiasis and
       hairy leukoplakia are among the most common manifestations. A careful
       oral examination should be included in the clinical evaluation of all
       HIV-infected hemophiliacs.
 DE    Blood Transfusion/*ADVERSE EFFECTS  Hemophilia/*COMPLICATIONS  Human
       HIV Seropositivity/*COMPLICATIONS  Male  Mouth
       Diseases/*COMPLICATIONS/EPIDEMIOLOGY  Prevalence  Retrospective Studies
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).