Document 0641
 DOCN  M9490641
 TI    Epidemiology of genital herpes.
 DT    9411
 AU    Kinghorn GR; Department of Genitourinary Medicine, Royal Hallamshire
       Hospital,; Sheffield, UK.
 SO    J Int Med Res. 1994;22 Suppl 1:14A-23A. Unique Identifier : AIDSLINE
       MED/94341479
 AB    New serological methods, based on the detection of type-specific
       antibodies to herpes simplex virus (HSV) glycoproteins, have allowed a
       reappraisal of the prevalence of genital herpes. During the 1980s,
       genital herpes continued to be an infection of epidemic proportions in
       many developed countries. In the USA, although there was evidence of a
       decline in the age-specific prevalence of HSV type 1 (HSV-1) infection,
       the seroprevalence of HSV type 2 (HSV-2) has continued to increase.
       Among those attending sexually transmitted disease clinics in the USA,
       30-50% of adults now have antibodies to HSV-2. Only a minority of HSV-2
       infected persons present with clinical disease related to this
       infection. In some countries, an increase in the incidence of severe
       primary genital infections caused by HSV-1, which often occur in
       monogamous relationships, has been reported. Genital ulcer disease, of
       which genital herpes is the most common cause in developed countries, is
       an important risk factor for the acquisition and transmission of human
       immunodeficiency virus (HIV) infection. Furthermore, evidence is
       accruing for a potential role of HSV reactivation in the progression of
       immune deficiency in HIV-infected individuals.
 DE    Adult  Age Factors  England/EPIDEMIOLOGY  Female  Herpes
       Genitalis/COMPLICATIONS/*EPIDEMIOLOGY/TRANSMISSION  Herpesvirus 1, Human
       Herpesvirus 2, Human  Human  HIV Infections/COMPLICATIONS  Male
       Recurrence  Sweden/EPIDEMIOLOGY  United States/EPIDEMIOLOGY  Virus
       Shedding  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

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