Document 0652
 DOCN  M9490652
 TI    High serum prolactin levels in asymptomatic HIV-infected patients and in
       patients with acquired immunodeficiency syndrome.
 DT    9411
 AU    Graef AS; Gonzalez SS; Baca VR; Ramirez ML; Daza LB; Blanco FF; Ortiz
       OA; Lavalle CM; Nuclear Medicine Department, Hospital de Especialidades,
       Centro; Medico La Raza, Mexico City, Mexico.
 SO    Clin Immunol Immunopathol. 1994 Sep;72(3):390-3. Unique Identifier :
       AIDSLINE MED/94340814
 AB    Prolactin (PRL) is an immunostimulatory hormone that is increased in
       serum of patients with systemic lupus erythematosus (SLE). On the other
       hand, SLE and AIDS patients share some clinical and immunologic
       manifestations and probably share similar pathogenic factors and
       etiology. Based on the above, we decided to investigate the serum PRL
       levels in 22 asymptomatic HIV-infected patients, 32 patients with AIDS,
       9 seronegative homosexual men, and 66 healthy controls. Antibodies to
       HIV were determined by a micro-ELISA system and by HIV-1 Western blot.
       Serum PRL was assayed by monoclonal antibodies. Serum PRL levels in the
       control group were 5.07 +/- 1.36 ng/ml and in the seronegative
       homosexual men were 5.81 +/- 1.45 ng/ml. Serum PRL levels in
       asymptomatic HIV-infected patients were 9.22 +/- 3.3 ng/ml and in AIDS
       patients were 10.26 +/- 2.5 ng/ml (P < 0.01 and P < 0.001, respectively,
       for both groups when compared to healthy controls). The difference
       between seronegative homosexual men and AIDS patients was P < 0.05. In
       the present study we found that serum PRL levels in AIDS patients are
       higher than in seronegative homosexual men and healthy controls; these
       results are in agreement with a previous published report. Since PRL is
       related to lymphocyte activation and lymphoproliferation, the finding
       may have monitoring, prognostic, and therapeutic implications.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/IMMUNOLOGY  Adolescence  Adult
       Human  HIV Infections/*BLOOD/IMMUNOLOGY  Male  Middle Age
       Prolactin/*BLOOD/PHYSIOLOGY  JOURNAL ARTICLE

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