Document 0657
 DOCN  M9490657
 TI    HIV and T cell expansion in splenic white pulps is accompanied by
       infiltration of HIV-specific cytotoxic T lymphocytes.
 DT    9411
 AU    Cheynier R; Henrichwark S; Hadida F; Pelletier E; Oksenhendler E; Autran
       B; Wain-Hobson S; Unite de Retrovirologie Moleculaire Institut Pasteur,
       Paris,; France.
 SO    Cell. 1994 Aug 12;78(3):373-87. Unique Identifier : AIDSLINE
       MED/94340729
 AB    Human immunodeficiency virus (HIV) replication and T cell proliferation
       were investigated in situ by a PCR-based analysis of individual
       microdissected splenic white pulps. Founder effects, revealed by an
       exquisite compartmentalization of HIV genotypes and T cells, indicated
       the recruitment of latently infected CD4+ T cells through highly
       localized antigen presentation rather than the infection of CD4+ T
       lymphoblasts by blood-borne virus or immune complexes. HIV-infected
       white pulps could be infiltrated by HIV-specific cytotoxic T
       lymphocytes, thereby implicating them in CD4+ T cell destruction in
       vivo. Together these data describe an iterative and deleterious
       mechanism of antigen-driven T cell recruitment and activation, as well
       as HIV replication and spread, with consequent destruction of the newly
       infected cells.
 DE    Amino Acid Sequence  Antigen Presentation  Base Sequence  Cell Movement
       Comparative Study  Human  HIV/GROWTH & DEVELOPMENT/*GENETICS  HIV
       Seropositivity/*IMMUNOLOGY  Lymphocyte Transformation  Molecular
       Sequence Data  Polymerase Chain Reaction  Proviruses/GROWTH &
       DEVELOPMENT/GENETICS  Receptors, Antigen, T-Cell, alpha-beta/GENETICS
       Sequence Homology, Amino Acid  Spleen/CYTOLOGY/*IMMUNOLOGY  Support,
       Non-U.S. Gov't  T-Lymphocyte Subsets/*IMMUNOLOGY  T-Lymphocytes,
       Cytotoxic/*IMMUNOLOGY  T4 Lymphocytes/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).