Document 0674
 DOCN  M9490674
 TI    Host defense abnormalities as causes of increased susceptibility to
       infections in children with HIV infection [editorial]
 DT    9411
 AU    Roilides E
 SO    Int J Med Microbiol Virol Parasitol Infect Dis. 1994 Mar;280(4):433-8.
       Unique Identifier : AIDSLINE MED/94339572
 AB    Infection with human immunodeficiency virus (HIV) is followed by an
       increased susceptibility to a series of opportunistic and common
       pathogenic organisms that can be viruses, bacteria, fungi or protozoa.
       This increased susceptibility has been associated with multiple defects
       underlying the whole spectrum of host defenses. Numerical and functional
       deficiencies in CD4+ T lymphocytes are the hallmark of progression of
       the disease. In addition, B cells become affected as evidenced by a
       spontaneous hyperproduction of immunoglobulins which are, however,
       dysfunctional, and an impaired production of specific antibodies in
       response to a variety of antigens. Natural killer cell cytotoxicity is
       also defective. Both monocytes/macrophages and neutrophils are affected
       by HIV and exhibit defective chemotactic and bactericidal function as
       well as defective antibody dependent cellular cytotoxicity and certain
       antifungal activities. These defects may explain the heightened
       frequency of infections in this population of patients, especially in
       children. Restoration of them with specific immunotherapeutic agents may
       decrease the incidence of infections.
 DE    B-Lymphocytes/IMMUNOLOGY  Child  Human  HIV Infections/*IMMUNOLOGY
       Immune System/*PHYSIOPATHOLOGY  Neutrophils/PHYSIOLOGY
       T-Lymphocytes/IMMUNOLOGY  EDITORIAL  REVIEW  REVIEW, TUTORIAL  JOURNAL
       ARTICLE

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