Document 0677
 DOCN  M9490677
 TI    Striking similarities between HIV-1 Env protein and the apoptosis
       mediating cell surface antigen Fas. Role in the pathogenesis of AIDS.
 DT    9411
 AU    Zagury JF; Cantalloube H; Achour A; Cho YY; Fall L; Lachgar A; Chams V;
       Astgen A; Biou D; Picard O; et al; Laboratoire de Physiopathologie
       Cellulaire, Universite P & M; Curie, Paris, France.
 SO    Biomed Pharmacother. 1993;47(8):331-5. Unique Identifier : AIDSLINE
       MED/94339406
 AB    We have designed a computer strategy in order to detect systematically
       peptidic sites with the potential of interfering with the immune
       regulatory processes. Applying this software to HIV-1 proteins has led
       us to unravel a few peptidic sites which could either act directly or be
       the targets of an auto-immune reaction during HIV-1 infection. We
       previously reported that the SLWDQ pentapeptide identity with a critical
       site of CD4 could trigger in HIV-1 infected individuals both an humoral
       and a cellular autoimmune reaction. In this study, we focused on
       surprising similitudes unravelled by our software Automat, between
       HIV-1/2 and another immunoregulatory molecule, the Fas protein which is
       also called the apoptosis-mediating cell-surface antigen.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/METABOLISM  Antigens,
       CD4/CHEMISTRY/IMMUNOLOGY  Antigens, Surface/*CHEMISTRY  HIV Envelope
       Protein gp120/*CHEMISTRY/IMMUNOLOGY  *HIV-1  In Vitro  Sequence
       Homology, Amino Acid  Software  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).