Document 0681
 DOCN  M9490681
 TI    [Progressive multifocal leukoencephalopathy and AIDS. Response to
       cytarabine]
 DT    9411
 AU    Hervas Laguna MJ; Nieto Rodriguez JA; Geijo Martinez MP; Ruiz Ribo MD;
       Borregon S; Servicio de Medicina Interna, Hospital Virgen de la Luz.,
       Cuenca.
 SO    An Med Interna. 1994 May;11(5):241-3. Unique Identifier : AIDSLINE
       MED/94339280
 AB    PML affects 4% of patients with AIDS and there is no effective
       treatment. Five cases of PML-AIDS have been described, showing clinical
       and radiological improvement after treatment with C-ara. We describe the
       case of a 33-year-old woman, addict to heroin, her clinical record
       including VIH infection, pneumonia by P. carinii, milliary tuberculosis,
       infection by virus B and C and treatment with AZT and tuberculostatics
       since January, 1992. In May, she began to develop a cerebellar syndrome.
       Images obtained with nuclear magnetic resonance were typical of PML.
       Subsequently, treatment with C-ara (2 mg/kg/day IV during 5 days each
       4-6 weeks) was begun. From the third month of treatment on, the patient
       showed a clinical improvement and as of the sixth month, the affected
       areas of white substance were reduced in size. In addition, CD4
       improved. Although in this patient a positive effect was observed after
       treatment with C-area, it should be verified in a controlled clinical
       trial.
 DE    Adult  AIDS-Related Opportunistic Infections/*DRUG THERAPY  Case Report
       Cytarabine/*THERAPEUTIC USE  English Abstract  Female  Human
       Leukoencephalopathy, Progressive Multifocal/*DRUG THERAPY  JOURNAL
       ARTICLE

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