Document 0684
 DOCN  M9490684
 TI    [Initial clinicopathological manifestations of malignant
       lymphoproliferative processes in patients with human immunodeficiency
       virus seropositivity. Study of 40 cases]
 DT    9411
 AU    Bellmunt J; Ribas A; Ocana I; Capdevila JA; Ruiz-Marcellan MC; Giralt J;
       Sole LA; Seccion de Oncologia Medica, Unidad de Enfermedades;
       Infecciosas, Hospital General Vall d'Hebron, Barcelona.
 SO    An Med Interna. 1994 May;11(5):217-23. Unique Identifier : AIDSLINE
       MED/94339274
 AB    We analyzed the series of 40 malignant lymphoproliferative diseases
       (MLD) in HIV positive patients, diagnosed between 1986 and 1993 in a
       University Hospital in Spain. Median age was 32 years. 52% of the
       patients belonged to the intravenous drug users risk group, and 30% were
       homosexual. 26 patients were diagnosed of a non-Hodgkin's lymphoma
       (NHL), 8 of Hodgkin's disease (HD) and 6 of a primary central nervous
       system lymphoma (PCL). The 6 patients with a PCL (median CD4 of 20
       cells/mm3, 80% antecedent AIDS criteria) and 13 NHL with histology of
       immunoblastic, large cell, plasmablastic, and high grade lymphoma
       non-otherwise specified (median CD4 of 291, 58% with AIDS criteria)
       tended to appear in patients with a deteriorated clinical and
       immunological status due to the underlying HIV infection. However, the
       14 small non-cleaved cell NHLs appeared in patients without a previous
       AIDS-defining condition (93% of the cases, p = 0.065 compared with other
       NHL histologies). Finally, 8 patients with HD had a low CD4 cell count
       (median 103 cells/mm3, p = 0.049 compared with median CD4 in NHL
       patients) without other previous AIDS criteria. In conclusion, The
       presenting characteristics of HIV positive patients with MLD allows to
       define four subgroups of patients with a high clinicopathological
       correlation.
 DE    Adolescence  Adult  Central Nervous System Neoplasms/PHYSIOPATHOLOGY
       English Abstract  Female  Hodgkin's Disease/PHYSIOPATHOLOGY  Human  HIV
       Seropositivity/*PHYSIOPATHOLOGY  Lymphoma/PHYSIOPATHOLOGY  Lymphoma,
       AIDS-Related/*PHYSIOPATHOLOGY  Lymphoma, Non-Hodgkin's/PHYSIOPATHOLOGY
       Male  Middle Age  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).