Document 0707
 DOCN  M9490707
 TI    Methadone treatment as a determinant of HIV risk reduction among
       injecting drug users: a nested case-control study.
 DT    9411
 AU    Serpelloni G; Carrieri MP; Rezza G; Morganti S; Gomma M; Binkin N;
       Gruppo C, ULSS-25, Verona, Italy.
 SO    AIDS Care. 1994;6(2):215-20. Unique Identifier : AIDSLINE MED/94339212
 AB    In order to evaluate the protective effect of methadone treatment on HIV
       infection, we performed a nested case-control study on seroconverters
       (cases) who were part of a cohort of HIV-negative injecting drug users
       (IDUs) (controls). Controls were matched with cases by sex, age,
       duration of drug use and follow-up time. Information on methadone
       treatment in the year prior to seroconversion was collected using
       clinical registries. Univariate and multivariate conditional logistic
       regression were used to identify variables related to
       HIV-seroconversion. The study included 40 cases and 40 controls.
       Univariate analysis showed the following variables to be associated to
       HIV seroconversion: number of cycles of treatment, daily dose and time
       out of treatment. After performing multivariate analysis, daily dose
       remained protective with a linear effect noted even at low doses and
       time out of treatment was the most important risk factor. The risk
       increased 1.5 times for every 3 months spent out of treatment. Long-term
       methadone treatment protects against HIV infection. Its effect may be
       attributable to a reduction in the frequency of injecting drug use or to
       an increased knowledge of risk factors following counselling in drug
       centres.
 DE    Adolescence  Adult  Case-Control Studies  Cohort Studies  Dose-Response
       Relationship, Drug  Drug Administration Schedule  Female  Follow-Up
       Studies  Human  HIV Infections/*PREVENTION &
       CONTROL/PSYCHOLOGY/TRANSMISSION  Italy  Knowledge, Attitudes, Practice
       Longitudinal Studies  Male  Methadone/ADVERSE EFFECTS/*THERAPEUTIC USE
       Middle Age  Narcotic Dependence/COMPLICATIONS/PSYCHOLOGY/*REHABILITATION
       Patient Education  Prospective Studies  Risk Factors  Substance Abuse,
       Intravenous/COMPLICATIONS/PSYCHOLOGY/  *REHABILITATION  JOURNAL ARTICLE

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