Document 0757
 DOCN  M9490757
 TI    Impaired alveolar macrophage accessory cell function and reduced
       incidence of lymphocytic alveolitis in HIV-infected patients who smoke.
 DT    9411
 AU    Twigg HL 3rd; Soliman DM; Spain BA; Department of Medicine, Indiana
       University Medical Center,; Indianapolis 46202.
 SO    AIDS. 1994 May;8(5):611-8. Unique Identifier : AIDSLINE MED/94338596
 AB    OBJECTIVE: To determine the effects of smoking on alveolar macrophage
       (AM) accessory cell (AC) function and the incidence of lymphocytic
       alveolitis in asymptomatic HIV-infected individuals. METHODS: AM AC
       function in smoking and nonsmoking HIV-positive volunteers was measured
       in concanavalin A and pokeweed mitogen assays. Mitogen-induced AM-T-cell
       adherence was determined. AM cytokine secretion was analyzed by
       interleukin (IL)-6 bioassay and IL-1 enzyme-linked immunosorbent assay
       (ELISA). The incidence of lymphocytic alveolitis in both groups was
       determined. RESULTS: AM from smokers were significantly poorer AC than
       AM from nonsmokers. Though AM-T-cell adherence was unaffected by
       smoking, IL-1 and IL-6 secretion was significantly impaired. Lymphocytic
       alveolitis was significantly less common in HIV-infected smokers.
       CONCLUSION: Smoking reduces AM AC function in HIV-infected individuals,
       probably by impairing secretion of cytokines important in T-cell
       proliferation. This may explain the decreased incidence of lymphocytic
       alveolitis in HIV-infected people who smoke.
 DE    Adult  Antigen-Presenting Cells/*IMMUNOLOGY/PATHOLOGY  Bronchoalveolar
       Lavage Fluid  Cell Adhesion  Cytokines/DEFICIENCY  Female  Human  HIV
       Infections/*COMPLICATIONS/IMMUNOLOGY  Incidence  Lung Diseases/*ETIOLOGY
       Lymphocyte Transformation  Macrophages, Alveolar/*IMMUNOLOGY/PATHOLOGY
       Male  Smoking/*IMMUNOLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  T-Lymphocytes, Cytotoxic/IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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