Document 0763
 DOCN  M9490763
 TI    The effect of alcohol consumption on nutritional status during murine
       AIDS.
 DT    9411
 AU    Wang Y; Liang B; Watson RR; Department of Family and Community Medicine,
       University of; Arizona, Tucson 85724.
 SO    Alcohol. 1994 May-Jun;11(3):273-8. Unique Identifier : AIDSLINE
       MED/94338580
 AB    As alcohol (ETOH) abusers and AIDS patients have nutritional disorders,
       the influence of chronic ETOH consumption (5% v/v for 10 weeks) on
       levels of immunomodulatory nutrients (vitamins A and E, Zn, and Cu) in
       the serum, liver, small intestine, spleen, and thymus was determined
       during murine AIDS. The hepatic levels of vitamins A and E and Zn in
       both normal and LP-BM5 retrovirus-infected female C56BL/6 mice fed ETOH
       were significantly reduced compared to controls, whereas the level of Cu
       in the liver was not affected. Intestinal levels of vitamin A and Cu
       were not affected by ETOH, whereas vitamin E and Zn were significantly
       reduced in both normal mice and those with AIDS fed ETOH. The splenic
       levels of vitamin A and Zn in the normal mice were significantly reduced
       by ETOH compared to controls, but vitamin E and Cu were not. All splenic
       levels of nutrients measured were reduced in ETOH-fed mice with AIDS.
       The levels of vitamins A and E, Zn, and Cu in the thymus in murine AIDS
       were also significantly affected by ETOH consumption. The serum levels
       of vitamins A and E in both normal mice and murine AIDS were
       significantly decreased by dietary ETOH. These data produced evidence
       that chronic ETOH can directly aggravate undernutrition initiated by
       retrovirus infection. Such ETOH-induced malnutrition in AIDS may be a
       cofactor, accelerating development of AIDS via immunosuppression
       secondary to nutritional deficiencies.
 DE    Alcohol, Ethyl/ADMINISTRATION & DOSAGE/*PHARMACOLOGY  Animal
       Copper/BLOOD/METABOLISM  Female  Intestines/DRUG EFFECTS/METABOLISM
       Liver/DRUG EFFECTS/METABOLISM  Mice  Mice, Inbred C57BL  Murine Acquired
       Immunodeficiency Syndrome/*PHYSIOPATHOLOGY  *Nutritional Status
       Spleen/DRUG EFFECTS/METABOLISM  Support, U.S. Gov't, P.H.S.  Thymus
       Gland/DRUG EFFECTS/METABOLISM  Vitamin A/BLOOD/METABOLISM  Vitamin
       E/BLOOD/METABOLISM  Zinc/BLOOD/METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).