Document 0003
 DOCN  M94A0003
 TI    Signals transduced through the CD4 molecule on T lymphocytes activate
       NF-kappa B.
 DT    9412
 AU    Chirmule N; Kalyanaraman VS; Pahwa S; Department of Pediatrics, North
       Shore University Hospital-Cornell; University Medical College,
       Manhasset, NY 11030.
 SO    Biochem Biophys Res Commun. 1994 Aug 30;203(1):498-505. Unique
       Identifier : AIDSLINE MED/94354848
 AB    We have demonstrated that native envelope glycoproteins of HIV-1, gp160
       can induce activation of the transcription factor, NF-kappa B. The
       stimulatory effects of gp160 are mediated through the CD4 molecule,
       since pretreatment with soluble CD4 abrogates its activity. The
       gp160-induced NF-kappa B complex consists of p65, p50 and c-rel
       proteins. The stimulatory effect of gp160 on NF-kappa B activation is
       protein synthesis independent, is dependent upon protein tyrosine
       phosphorylation, and abrogated by inhibitors of protein kinase C. The
       gp160-mediated activation of NF-kappa B in CD4 positive T cells may be
       involved in biological effects, e.g., enhanced HIV replication,
       hypergammaglobulinemia, increased cytokine secretion, hypercellularity
       in bone marrow and apoptosis.
 DE    Antigens, CD/*PHYSIOLOGY  Antigens, CD4/DRUG EFFECTS/*PHYSIOLOGY  Cell
       Line  Cell Nucleus/METABOLISM  Cells, Cultured  Gene Products,
       env/*PHARMACOLOGY  Human  HIV/IMMUNOLOGY  NF-kappa B/*METABOLISM
       Protein Precursors/*PHARMACOLOGY  *Signal Transduction  Support, U.S.
       Gov't, P.H.S.  T-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY/*METABOLISM  Tumor
       Cells, Cultured  T4 Lymphocytes/DRUG EFFECTS/IMMUNOLOGY/*PHYSIOLOGY
       JOURNAL ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).