Document 0011
 DOCN  M94A0011
 TI    Langerhans' cells and lymphocytic infiltrate in AIDS-associated Kaposi's
       sarcoma. An immunohistochemical study.
 DT    9412
 AU    Valcuende-Cavero F; Febrer-Bosch MI; Castells-Rodellas A; Dermatology
       Unit, Hospital Gran Via, Castellon, Spain.
 SO    Acta Derm Venereol. 1994 May;74(3):183-7. Unique Identifier : AIDSLINE
       MED/94353823
 AB    The epidermal Langerhans' cells are dendritic cells of the skin capable
       of triggering cutaneous immune responses. They possess the membrane
       antigens required to this effect: class II histocompatibility antigen,
       CD1a and CD4; the latter acts as receptor for the human immunodeficiency
       virus. The skin is the organ primarily affected by Kaposi's sarcoma
       (KS). In epidemic KS, the local immunologic conditions of the skin are
       little known. We therefore studied 12 patients with AIDS-associated KS,
       evaluating the density and phenotypic expression in KS-affected and
       unaffected skin of the following antigens: CD1a, HLA-DR, CD4 in
       dendritic epidermal cells and dermis, and CD3, CD4 and CD8 in cells of
       the inflammatory infiltrate, using monoclonal antibodies applied to
       frozen sections with the avidin-biotin-peroxidase technique. Langerhans'
       cells in the AIDS-KS skin lesions were found to be decreased in number.
       This decrease was even more pronounced in the case of cells expressing
       HLA-DR antigen. A number of them were also revealed with CD4. The tumour
       lymphocytic infiltrate was almost exclusively composed of CD3+ CD8+
       phenotype lymphocytes. The dermis also revealed CD4+ dendritic cells.
       The basal keratinocytes focally expressed HLA-DR. These phenotypical
       alterations of the Langerhans' cells and the local immunological
       imbalance observed may contribute to the growth and continuity of the KS
       lesions.
 DE    Antigens, CD/ANALYSIS  Antigens, CD3/ANALYSIS  Antigens, CD4/ANALYSIS
       Antigens, CD8/ANALYSIS  AIDS-Related Complex/IMMUNOLOGY/*PATHOLOGY
       Female  Human  HLA-DR Antigens/ANALYSIS  Immunohistochemistry
       Langerhans Cells/IMMUNOLOGY/*PATHOLOGY  Lymphocytes,
       Tumor-Infiltrating/IMMUNOLOGY/*PATHOLOGY  Male  Sarcoma,
       Kaposi's/IMMUNOLOGY/*PATHOLOGY  Skin Neoplasms/IMMUNOLOGY/*PATHOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).